JQ1 inhibited apoptosis and ERS induced by renal IRI in mice. (A) Representative images of TUNEL staining on kidney sections (×400). (B) Western blots of Bax,Bcl-2, Caspse-3 at 24 h of reperfusion time, and bar graph showing the fold changes of Bax,Bcl-2, Caspse-3 relative to sham group from three independent samples. (C) Immunohistochemical staining of Caspse-3 in renal tissues at 24 h of reperfusion time. (D) Western blots of GRP78, CHOP at 24 h of reperfusion time, and bar graph showing the fold changes of GRP78, CHOP. Values are expressed as the mean ± SEM. *P < 0.05, relative to sham group; #P < 0.05, relative to vehicle control.