Table 5.

Results for multiple regression analyses of ROI mean diffusivity (MD).

ROI	Model				Group		Age		Gender		TBV
		R2adj	F	p	β	p	β	p	β	p	β	p
Right hippocampus	1	0.16	4.49	.007	−0.26	.044a	−0.32	.015	−0.10	.42
	2	0.24	5.35	.001	−0.28	.027b	−0.02	.90	0.08	.52	0.42	.014
Left hippocampus	1	0.07	2.45	.07	−0.8	.57	−0.33	.016	−0.01	.96
	2	0.10	2.51	.05	−0.08	.53	−0.13	.48	0.01	.95	0.29	.12
Right amygdala	1	0.32	9.54	4*10−5	0.11	.36	−0.61	3*10−6	−0.18	.12
	2	0.33	7.60	7*10−5	0.10	.39	−0.47	.005	−0.17	.14	0.19	.23
Left amygdala	1	0.20	4.27	.009	−0.08	.54	−0.34	.011	−0.30	.021
	2	0.15	3.31	.018	−0.08	.53	−0.25	.17	−0.29	.026	0.13	.47
Putamen	1	0.03	1.56	.21	−0.12	.38	−0.22	.12	0.10	.47
	2	0.45	11.96	7*10−7	0.15	.16	0.42	.006	0.15	.15	0.89	1*10−7
Caudate nucleus	1	0.21	5.80	.002	−0.05	.67	−0.47	.0004	0.12	.35
	2	0.44	11.68	9*10−7	−0.07	.50	0.01	.95	0.15	.14	0.67	2*10−5
Nucleus accumbens	1	−0.03	0.54	.66	−0.06	.68	−0.12	.40	0.09	.52
	2	0.12	2.92	.030	−0.07	.58	0.27	.14	0.12	.35	0.56	.003

In models 1(Degrees of freedom: = 3, 56), group, age and gender were used as independent variables. In models 2 (Degrees of freedom: = 3, 56), group, age, gender and global MD were used as independent variables. Negative β-values reflect lower MD in patients compared to controls or lower MD in girls compared to boys. Analyses included 28 controls and 27 patients. ROI = Region-of-interest, M = Model, R = Right, L = Left. P values <.05 are displayed in italic bold. Effect sizes are expressed as squared semi-partial correlations (Sr²), which represent the proportion of the outcome variance that is associated uniquely with the predictor.

^aSr²_{(model 1, right hippocampus, group)} = 0.07.

^bSr²_{(model 2, right hippocampus, group)} = 0.07.