FIG 4.
Us11 contributes to virulence. (A) Wild-type 129SvEv mice were injected intracranially with 100 PFU of strain 17, strain 17Δ11, or strain 17Δ34.5 and euthanized when endpoint criteria were met. (B and C) Wild-type 129SvEv mice were subjected to corneal infection following scarification. Inoculation of either 2 × 106 PFU/eye (B) or 104 PFU/eye (C) of the indicated viruses was performed, and mice were euthanized when endpoint criteria were met. P values determined using the log rank (Mantel-Cox) test and numbers of animals per group are as indicated.