FIG 5.
Viral replication in mouse tissues. Corneas of wild-type 129SvEv mice were scarified and infected with 2 × 106 PFU/eye of strain 17, strain 17Δ11, or strain 17Δ11R. (A) At 24 and 48 hpi, eyes were swabbed and titers of virus in tear film were determined. The number of animals per group is indicated in the key. (B and C) Mice were sacrificed on days 3 and 5, and titers of virus were determined in trigeminal ganglia (B) and periocular tissue (C). Numbers within bars indicate the total number of animals in each group. Error bars show the standard deviations. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (two-way ANOVA and Bonferroni posttests).