FIG 6.
Us11 promotes periocular pathogenesis. Corneas of wild-type 129SvEv and C57BL/6J mice were scarified and infected with 2 × 104 PFU/eye (129SvEv) or 2 × 106 PFU/eye (C57BL/6J) of strain 17, strain 17Δ11, or strain 17Δ11R. Mice were scored for disease daily from disease onset until resolution of periocular disease by an observer in a blind fashion. (A) Using the scoring metrics in the table (right), the mean numerical disease score on the day of maximal disease is shown for each virus/host strain combination (left). The number of animals per group is shown inside each bar. **, P < 0.01; ***, P < 0.001 (one-way ANOVA and Bonferroni posttests). (B and C) Data from the same experiment are shown as percentages of total days following infection in which the mean disease score equaled or exceeded 0.85 (129SvEv [SvEv] mice) (B) or 0.25 (C57BL/6J [Bl6] mice) (C).