Table 3.

Decreased gray matter intensity signals in FTD predicted by interaction effects between diagnostic group and DRD₄ polymorphisms with dampened function.

Anatomic region	MNI Coordinates			Peak T-value	Cluster Size
	X	Y	Z
Right ventral ACC/vmPFC	10	44	10	5.24
Right dorsal ACC/dmPFC	8	28	28	4.60	2178
Right ventral ACC/medial OFC	4	42	−20	4.29
Right anterior insula	27	22	−15	4.51
Right lateral OFC	42	27	2	4.19	720
Right mid-insula	38	−4	9	3.87
Left ventral ACC	−8	45	16	4.45	299

Abbreviations: MNI = Montreal Neurologic Institute coordinate space, ACC = anterior cingulate cortex, vmPFC = ventromedial prefrontal cortex, dmPFC = dorsal medial prefrontal cortex, OFC = orbitofrontal cortex. Cluster size is listed at the voxel-level (voxel size is 1.5 mm³). Results are significant at p_FWE-corr < 0.05.