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. 2019 Apr 19;11:1759091419843393. doi: 10.1177/1759091419843393

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© The Author(s) 2019

Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 9. — Loss of circadian rhythm gene expression in Tpp1^–^/^– brains. Loss of Per1 mRNA expression in PIR (a and b) and the SCH (c and d) in Tpp1^–^/^– (b, d) 4-month-old brains compared with control heterozygous (a, c). Canonical pathway analysis by IPA highlights the genes affected in the circadian rhythm signaling pathways for F/M (e) and Cb (f). Involved DEG detected by RNA-seq analysis and change ratio (l2fc=log₂ of T vs. N ratio) are indicated.

PIR = piriform cortex; SCH = suprachiasmatic nuclei.