Table 5.
The effect of metformin on the morphometric parameters of rat pancreatic islets
| Group | Total β-cell area | Mean islet area, μm2 | Number of islets | ||
|---|---|---|---|---|---|
| absolute, μm2 | % of the islet area | ||||
| 1 | Passive control | 225,270±17,005 | 20.0±1.3 | 18,477±2,142 | 12±1 |
| 2 | Active control | 70,181±20,313** | 5.8±2.1** | 7,646±1,654** | 9±2 |
| 3 | Metformin | 115,353±23,845 | 10.1±0.8* | 9,749±1,714 | 12±2 |
*– Statistical significance of differences between the experimental group and active control, p < 0.05.
**– Statistical significance of differences between passive and active control, p < 0.05.