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The mechanisms of action of ASIC1a ligands. A – the effect of histamine on the recombinant ASIC1a expressed in CHO cells. Histamine does not affect the maximal response (caused by a pH decrease from 7.6 to 5.0) but potentiates the partial response (pH decrease from 7.6 to 6.5), especially under conditions of partial desensitization (pH decrease from 7.1 to 6.5). B – pH dependences of ASIC1a activation and desensitization. The arrows show the directions of the shifts caused by ligands
