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Binding sites of ASIC 1a ligands according to structural studies. A – MitTx that activates the channels and binds to the palm domain; B – psalmotoxin binds to the upper portion of the palm domain, and the central loop penetrates the acidic pocket; C – three amiloride molecules bind at the interfaces to membrane-spanning helices; D – two amiloride molecules form a dimer, which binds in the acidic pocket
