Table 2.
Cytotoxicity (IC50 μgLW/ml) of extracts against Human cell lines
| Extracts | Flo-1 | OE 33 | OE 19 | KYSE-30 | HeLa | HCT 116 | Fibroblast | RPE1 |
|---|---|---|---|---|---|---|---|---|
| A. integrifolia | 10.43 ± 2.10 [SI = 4.2]c* |
28.03 ± 4.21 [SI = 1.6]a**** |
39.28 ± 7.52 [SI = 1.1]a |
6.42 ± 2.21 [SI = 6.9]a |
7.67 ± 1.58 [SI = 5.7]a |
14.51 ± 1.23 [SI = 3.0]b,c**** |
36.93 ± 6.41 b**** |
43.99 ± 4.76 a,b**** |
| D. acutangula | 45.72 ± 7.93 [SI = 0.8]a**** |
ND | ND | ND | 14.27 ± 2.97 [SI = 2.6]b**** |
14.13 ± 2.62 [SI = 2.7]c**** |
45.30 ± 4.33 a**** |
37.47 ± 4.50 b**** |
| E. tinifolia | 48.62 ± 3.24 [SI = 0.8]a**** |
45.72 ± 7.93 [SI = 0.9]b**** |
44.65 ± 8.87 [SI = 0.9]b |
6.99 ± 0.38 [SI = 5.6]a |
35.26 ± 5.01 [SI = 1.1]c**** |
19.54 ± 5.16 [SI = 2.0]b**** |
27.04 ± 1.84 c**** |
38.94 ± 4.10 b**** |
| L. glauca | 11.19 ± 2.53 [SI = 4.3]c* |
ND | ND | 9.22 ± 1.16 [SI = 5.2]b** |
41.53 ± 3.28 [SI = 1.2]d**** |
31.58 ± 5.25 [SI = 1.5]a**** |
26.74 ± 1.64 c**** |
48.49 ± 6.12 a**** |
| Etoposide | 5.23 ± 0.56 [SI = 3.1] |
6.74 ± 0.66 [SI = 2.4] |
ND | 7.05 ± 0.89 [SI = 2.3] |
5.47 ± 0.66 [SI = 3.0] |
4.93 ± 0.35 [SI = 3.3] |
10.24 ± 2.77 | 16.17 ± 3.93 |
Data represent mean IC50 values ± standard deviation (n = 3).
Selectivity index determined as a ratio of the IC50 immortalized RPE-1 normal cell to the IC50 of cancer cell lines is indicated.
ND = at 50 and 25 μg/ml the extracts and etoposide, respectively, failed to induce 50% growth; hence, no IC50 value was determined.
Different letters between the rows in each column represent significant differences between the extracts (p < 0.05).
Asterisks represent significant differences between the extracts and etoposide (positive control),
*p ≤ 0.05,
**p ≤ 0.01,
***p ≤ 0.001,
****p ≤ 0.0001.