Skip to main content
. Author manuscript; available in PMC: 2019 Apr 22.
Published in final edited form as: J Control Release. 2017 Nov 13;269:364–373. doi: 10.1016/j.jconrel.2017.11.021

Fig. 7.

Fig. 7.

CP-Dox prevention of metastasis is CD8+ T cell dependent in a surgical model of 4T1 mammary carcinoma. Metastasis free survival of mice inoculated with 4T1 and treated with CD8 depleting antibody or isotype control along with drug treatment and primary tumor resection (n = 7:5 CP-Dox, 6:5 Free Dox, 4:3 PBS for α-CD8:Iso Ctrl). CD8 depletion had no effect on the survival of Free Dox or PBS mice, but in CP-Dox treated mice, no mice survived to the end of the experiment in the setting of CD8 depletion (p < 0.05, Fisher’s Exact).