Table 4.
Quality of life before and after SBRT
| Pre-SBRT | 1 month | 3 months | 6 months | 12 months | |
| Number of returned questionnaires | 20 | 18 | 15 | 8 | 3 |
| Percentage of expected completiona | 100 | 90 | 88 | 80 | 100 |
| RAND-36 | |||||
| Physical functioning | 63.3 (27.5) | 60.0 (34.7) | 70.3 (28.1) | 71.9 (22.0) | 50.0 (42.7) |
| Social functioning | 51.9 (27.3) | 61.8 (30.5) | 70.0 (18.8)b | 67.2 (27.5) | 41.7 (26.0) |
| Physical role restriction | 30.0 (40.2) | 38.9 (42.2) | 45.0 (38.0) | 31.3 (32.0) | 8.3 (14.4) |
| Emotional role restriction | 42.6 (45.5) | 51.9 (43.1) | 47.6 (40.7) | 45.8 (43.4) | 33.3 (57.7) |
| Mental health | 64.6 (17.7) | 69.3 (22.2) | 72.3 (16.9) | 68.0 (17.1) | 68.0 (14.4) |
| Vitality | 53.3 (19.6) | 51.4 (22.1) | 57.3 (20.4) | 60.6 (24.7) | 26.7 (12.6) |
| Pain | 55.6 (25.1) | 74.8 (20.1)b | 72.9 (23.0) | 67.3 (17.9) | 51.7 (23.2) |
| General health | 45.1 (15.4) | 45.3 (19.9) | 44.7 (13.2) | 42.9 (17.8) | 26.7 (14.4) |
| Change in health | 20.0 (13.1) | 33.3 (29.7) | 35.0 (32.5) | 34.4 (39.9) | 16.7 (14.4) |
| EORTC QLQ-C30 | |||||
| Physical functioning | 71.4 (22.3) | 70.4 (27.8) | 76.9 (23.5) | 79.2 (16.9) | 53.3 (37.1) |
| Role functioning | 55.0 (23.6) | 63.9 (33.5) | 65.6 (20.4) | 56.3 (30.8) | 38.9 (34.7) |
| Emotional functioning | 67.1 (17.8) | 71.3 (26.1) | 77.2 (18.2) | 61.5 (24.4) | 61.1 (12.7) |
| Cognitive functioning | 81.7 (21.6) | 75.9 (30.9) | 81.1 (22.6) | 85.4 (18.8) | 77.8 (25.5) |
| Social functioning | 68.3 (24.1) | 69.6 (34.0) | 81.1 (20.8)b | 72.9 (26.6) | 55.6 (25.5) |
| Global health/QOL | 58.5 (16.2) | 62.3 (26.0) | 65.6 (18.3) | 57.3 (25.4) | 44.4 (12.7) |
| Fatigue | 40.0 (22.6) | 37.7 (24.1) | 37.0 (25.1) | 47.2 (21.2) | 74.1 (25.7) |
| Nausea and vomiting | 11.7 (16.3) | 14.8 (27.9) | 8.9 (13.9) | 22.9 (33.3) | 22.2 (19.2) |
| Pain | 35.0 (26.4) | 23.1 (23.0) | 26.7 (24.2) | 33.3 (21.8) | 50.0 (16.7) |
| Dyspnea | 15.8 (25.1) | 11.1 (22.9) | 15.6 (30.5) | 20.8 (24.8) | 22.2 (19.2) |
| Insomnia | 25.0 (35.7) | 22.2 (22.9) | 20.0 (27.6) | 37.5 (27.8) | 66.7 (33.3) |
| Appetite loss | 41.7 (34.0) | 33.3 (37.9) | 28.9 (35.3) | 33.3 (35.6) | 33.3 (33.3) |
| Constipation | 23.3 (30.8) | 20.4 (34.6) | 15.6 (21.3) | 8.3 (23.6) | 0.0 (0.0) |
| Diarrhea | 21.7 (29.2) | 27.8 (36.6) | 28.9 (33.0) | 57.1 (37.1)b | 55.6 (50.9) |
| Financial difficulties | 6.7 (17.4) | 7.8 (14.6) | 8.9 (15.3) | 12.5 (24.8) | 0.0 (0.0) |
| EORTC QLQ-PAN26 | |||||
| Pain | 32.4 (24.9) | 23.5 (17.5) | 29.4 (21.6) | 35.4 (18.2) | 22.2 (9.6) |
| Eating related items | 31.7 (25.3) | 33.3 (34.4) | 24.4 (26.6) | 35.4 (27.4) | 27.8 (19.2) |
| Cachexia | 36.7 (22.7) | 35.3 (23.5) | 32.2 (23.1) | 56.3 (33.3) | 27.8 (25.5) |
| Hepatic | 18.3 (21.6) | 7.8 (14.6) | 3.3 (9.3)b | 14.6 (22.6) | 11.1 (9.6) |
| Body image | 20.8 (22.2) | 26.0 (26.5) | 21.1 (24.0) | 43.8 (28.1) | 27.8 (25.5) |
| Side effects | 22.8 (20.5) | 28.8 (28.3) | 23.0 (25.0) | 30.6 (25.7) | 25.9 (23.1) |
| Health-care satisfaction | 74.2 (21.9) | 69.8 (24.5) | 80.0 (20.1) | 76.2 (23.3) | 75.0 (35.4) |
| Altered bowel habit | 35.8 (26.6) | 35.3 (17.6) | 44.4 (24.1) | 47.9 (18.8) | 55.6 (9.6) |
| Sexuality | 41.7 (39.7) | 57.8 (36.9) | 47.6 (45.2) | 52.8 (40.0) | 38.9 (41.9) |
| Ascites | 35.0 (29.6) | 31.4 (22.0) | 37.8 (27.8) | 37.5 (33.0) | 44.4 (19.2) |
| Indigestion | 26.7 (31.7) | 29.2 (34.2) | 31.1 (34.4) | 28.6 (40.5) | 33.3 (33.3) |
| Flatulence | 48.3 (31.5) | 43.1 (30.7) | 42.2 (34.4 | 38.1 (23.0) | 44.4 (50.9) |
| Fear of future health | 61.7 (27.1) | 51.0 (29.1) | 51.1 (27.8) | 62.5 (21.4) | 55.6 (19.2) |
| Ability to plan future | 45.0 (27.1) | 39.2 (33.8) | 37.8 (33.0) | 41.7 (29.5) | 44.4 (50.9) |
EORTC, European Organization for Research and Treatment of Cancer; QOL, quality of life; SBRT, stereotactic body radiation therapy.
Values are mean (SD) unless indicated otherwise.
a
Values are percentage of expected replies after exclusion of censored patients (those who had died or within 1 month of dying) or not yet reached time point due to short follow- up.
b
p < 0.050 and clinically relevant (more than 10-point change in score) difference between baseline and postoperative time point (paired t test).