Table 2.
Comparison of pre-clinical cell tracking methods, data adapted and modified from,5, 61,62 we noted that Ultrasound and CT are not well characterized for tracking cells
| Modality | Resolution | Acquisition speed | Sensitivity/cells detected | Cell labeling agents |
| Optical | 20 µm/poor at depth | <Seconds | μM/1000 | Reporter gene/dyes (IcG, Cy, Luciferase) |
| Nuclear medicine | 1000–2000 µm | Minutes | pM/10,000–100,000 | Radionuclide (In111, Tc99m, 18F, 68Ga) |
| MRI | 25–500 µm | Minutes | mM/10,000 | Contrast agent (Gd, Mn, SPIO, 19F) |
| MPI | 250–1400 µm | Minutes | 0.1 µM/10– 200 | SPIO |
MPI, magnetic particle imaging; SPIO, superparamagnetic iron oxide nanoparticle.