Table 1.
Changes in relative levels of metabolites in the serum samples from CRC patients, colorectal polyp patients, and healthy controls.
| Metabolites | δ (1H) | Colorectal polyp vs. control | CRC vs. control | CRC vs. colorectal polyp | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| VIP | ∣r∣ | Change/fold change | VIP | ∣r∣ | Change/fold change | VIP | ∣r∣ | Change/fold change | ||
| Lipid | 0.83-0.89 (bra) | 2.51 | 0.41 | ↑∗/1.07 | 2.15 | 0.33 | ↓∗/1.19 | 2.24 | 0.36 | ↓∗/1.15 |
| Leucine | 0.96 (t), 1.70 (m), 3.73 (m) | 1.3 | 0.52 | ↑∗∗/1.08 | 1.16 | 0.45 | ↓∗∗/1.23 | 2.04 | 0.45 | ↓∗∗/1.16 |
| Isoleucine | 9.92 (t), 1.02 (d), 3.73 (m) | — | — | —/1.01 | 1.34 | 0.53 | ↑∗∗/1.28 | — | — | —/1.01 |
| Valine | 9.78 (d), 1.05 (d), 3.61 (d) | 1.92 | 0.54 | ↓∗∗/1.09 | 3.77 | 0.50 | ↓∗∗/1.17 | 3.03 | 0.35 | ↓∗/1.12 |
| 3-Hydroxybutyrate | 1.20 (d), 2.28 (q), 2.40 (q), 4.15 (m) | — | — | —/1.01 | 1.29 | 0.47 | ↑∗∗/1.59 | — | — | —/1.08 |
| Lactate | 1.33 (d), 4.12 (q) | 9.52 | 0.63 | ↑∗∗/1.51 | 4.6 | 0.67 | ↑∗∗/1.48 | — | — | —/1.06 |
| Alanine | 1.48 (d), 3.78 (q) | 1.13 | 0.56 | ↓∗∗/1.12 | 1.65 | 0.48 | ↓∗∗/1.17 | 2.19 | 0.36 | ↓∗/1.18 |
| Acetate | 1.92 (s) | 1.46 | 0.57 | ↑∗∗/1.21 | 1.25 | 0.54 | ↑∗∗/1.18 | — | — | —/1.02 |
| Glutamate | 2.08 (m), 2.34 (m) | 3.19 | 0.86 | ↑∗∗/1.41 | 1.95 | 0.72 | ↑∗∗/1.20 | 1.51 | 0.38 | ↑∗/1.18 |
| Glutamine | 2.13 (m), 2.45 (m) | 5.19 | 0.82 | ↓∗∗/1.19 | 2.74 | 0.67 | ↓∗∗/1.18 | 1.06 | 0.39 | ↓∗/1.19 |
| Succinate | 2.37 (s) | 2.57 | 0.63 | ↓∗∗/1.12 | 1.84 | 0.57 | ↓∗∗/1.23 | — | — | —/1.13 |
| Citrate | 2.54 (d), 2.66 (d) | — | — | —/1.01 | 2.92 | 0.61 | ↓∗∗/1.21 | 2.79 | 0.54 | ↓∗∗/1.17 |
| Aspartate | 2.87 (m), 2.94 (m) | 1.49 | 0.74 | ↓∗∗/1.40 | 1.51 | 0.76 | ↓∗∗/1.62 | — | — | —/1.09 |
| Choline | 3.20 (s) | 2.31 | 0.54 | ↑∗∗/1.23 | 2.1 | 0.48 | ↑∗∗/1.20 | — | — | —/1.02 |
| Proline | 3.36 (m) | — | — | —/1.03 | 4.03 | 0.65 | ↓∗∗/1.20 | 3.41 | 0.44 | ↓∗∗/1.26 |
| Glycine | 3.57 (s) | 2.62 | 0.48 | ↑∗∗/1.19 | 2.21 | 0.52 | ↑∗∗/1.46 | — | — | —/1.04 |
| Glucose | 3.24 (q), 3.48 (t), 3.90 (q), 3.54 (t), 3.71 (t), 3.83 (t) | 2.49 | 0.52 | ↓∗∗/1.25 | 1.87 | 0.67 | ↑∗∗/1.53 | 3.46 | 0.47 | ↑∗∗/1.31 |
| Serine | 3.84 (m), 3.96 (m) | 1.57 | 0.68 | ↑∗∗/1.32 | 1.19 | 0.59 | ↑∗∗/1.18 | 1.68 | 0.60 | ↑∗∗/1.23 |
| Tyrosine | 6.90 (d), 7.20 (d) | — | — | —/1.01 | 1.01 | 0.52 | ↓∗∗/1.19 | 1.12 | 0.54 | ↓∗∗/1.22 |
| NAc | 2.03 (s) | 1.09 | 0.62 | ↓∗∗/1.27 | — | — | —/1.01 | 2.93 | 0.74 | ↑∗∗/1.21 |
| PUFA | 2.76-2.83 (bra) | 1.1 | 0.41 | ↑∗/1.18 | — | — | —/1.04 | 1.46 | 0.43 | ↓∗∗/1.37 |
| Glycerol | 3.61 (m), 3.65 (m) | 1.74 | 0.61 | ↓∗∗/1.32 | — | — | —/1.07 | — | — | —/1.05 |
| Lysine | 1.45 (m), 1.71 (m), 1.89 (m), 3.02 (t), 3.75 (t) | — | — | —/1.02 | — | — | —/1.03 | 1.04 | 0.49 | ↑∗∗/1.26 |
s: single; d: doublet; dd: doublet of doublet; t: triplet; q: quartet; m: multiplet; bra: broad peak; ↑: increase; ↓: decrease; —: no significant change. ∗ p < 0.05; ∗∗ p < 0.01.