Table 2.
Univariate and multivariate analysis of prognostic factors for overall survival in gastric cancer patients.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | p > ∣z∣ | 95% CI | HR | p > ∣z∣ | 95% CI | |
| Gender | ||||||
| Male vs. female | 1.014 | 0.903 | (0.816, 1.258) | |||
| Age | ||||||
| ≤60 vs. >60 | 1.167 | 0.116 | (0.963, 1.413) | |||
| Histological type | ||||||
| Tubular vs. mucinous vs. mixed (tubular and mucinous) vs. signet ring cells vs. othersa | 1.018 | 0.698 | (0.930, 1.114) | |||
| Differentiation | ||||||
| Well vs. middle vs. poor | 1.526 | <0.001∗ | (1.273, 1.829) | 1.096 | 0.366 | (0.898, 1.339) |
| T | ||||||
| Tis vs. T1+T2 vs. T3+T4 | 2.723 | <0.001∗ | (2.207, 3.360) | 1.317 | 0.083 | (0.964, 1.798) |
| N | ||||||
| N0 vs. N1 vs. N2 vs. N3 | 1.700 | <0.001∗ | (1.568, 1.844) | 1.265 | 0.002∗ | (1.093, 1.463) |
| M | ||||||
| M0 vs. M1 | 3.503 | <0.001∗ | (2.556, 4.800) | 2.176 | <0.001∗ | (1.534, 3.088) |
| TNM stage | ||||||
| 0+I vs. II vs. III+IV | 2.686 | <0.001∗ | (2.331, 3.096) | 1.453 | 0.022∗ | (1.054, 2.004) |
| SALM3 expression in tumor cells | ||||||
| High vs. low or none | 1.785 | <0.001∗ | (1.473, 2.165) | 1.471 | <0.001∗ | (1.210, 1.789) |
| SALM3 expression in stroma | ||||||
| High vs. low or none | 2.262 | <0.001∗ | (1.868, 2.740) | 1.525 | <0.001∗ | (1.247, 1.865) |
| Combination of tumor cells and fibroblasts | ||||||
| I vs. IV | 2.137 | 0.023∗ | (1.124, 2.537) | 1.621 | 0.036∗ | (1.312, 2.472) |
| II vs. IV | 1.276 | 0.616 | (0.714, 2.328) | |||
| III vs. IV | 1.769 | 0.548 | (1.357, 2.664) | |||
∗ p < 0.05; aOthers: papillary adenocarcinoma, 5 cases; adenosquamous carcinoma, 6 cases; squamous cell carcinoma, 7 cases; undifferentiated carcinoma, 1 case; small cell malignant tumor, 9 cases; carcinoid, 2 cases; focal cancer, 2 cases. Four groups were classified according to the SALM3 expression in tumor cells and/or stroma: group I has low expression of both, group II has high expression of tumor cells and low expression of stroma, group III has low expression of tumor cells and high expression of stroma, and group IV has high expression of both.