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. 2019 Apr 7;2019:6734836. doi: 10.1155/2019/6734836

Figure 1.

Figure 1

Males are more prone to develop type 2 diabetes with age than females. Role of estrogen replacement therapy. (a) Evolution of glycaemia levels in male and female GK controls. The data are shown as means ± SD (n = 4 for both groups). The statistical significance is expressed as ∗p < 0.05. (b) Survival curve in male and female GK controls (n = 4 for both groups). (c) Evolution of glycaemia levels in female GK controls (n = 4), ovariectomized female GK (n = 6), and ovariectomized female GK + estradiol replacement (n = 6). The data are shown as means ± SD. (d) Evolution of weight in female GK controls (n = 4), ovariectomized female GK (n = 6), and ovariectomized female GK + estradiol replacement (n = 6). The data are shown as means ± SD. The statistical significance is expressed as #p < 0.05 for GK OVX versus GK OVX + E2. (e) Glucose tolerance test in female WISTAR controls (n = 6), female GK controls (n = 4), ovariectomized female GK (n = 6), and ovariectomized female GK + estradiol replacement (n = 6). The data are shown as means ± SD. The statistical significance is expressed as ∗∗p < 0.01 for WISTAR CTL versus GK CONTROL, ##p < 0.01 for WISTAR CTL versus GK OVX + E2, $$p < 0.01 for WISTAR CTL versus GK OVX, &p < 0.05 and &&p < 0.01 for GK OVX versus GK OVX + E2.