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. 2019 Apr 7;2019:6734836. doi: 10.1155/2019/6734836

Figure 4.

Figure 4

Type 2 diabetic female rats are protected against free radical production compared with type 2 diabetic male rats. Protective role of estrogen replacement therapy. (a) Mitochondrial hydrogen peroxide production in male WISTAR (n = 12), male GK (n = 8), female WISTAR (n = 14), and female GK (n = 8). The data are shown as means ± SD. The statistical significance is expressed as ∗p < 0.05 for male WISTAR versus male GK, ###p < 0.001 for male GK versus female GK, and &&&p < 0.001 for male WISTAR versus female WISTAR. (b) Mitochondrial hydrogen peroxide production in female WISTAR (n = 14), female GK (n = 4), ovariectomized female GK (n = 6), and ovariectomized female GK + estradiol replacement (n = 6). The data are shown as means ± SD. The statistical significance is expressed as &&p < 0.01 for WISTAR versus GK OVX, ∗∗p < 0.01 for GK versus GK OVX, and #p < 0.05 for GK OVX versus GK OVX + E2. (c) Xanthine oxidase activity levels in plasma of male WISTAR (n = 7), male GK (n = 8), female WISTAR (n = 5), and female GK (n = 8). The data are shown as means ± SD. The statistical significance is expressed as ###p < 0.001 for female GK versus male GK, ∗∗∗p < 0.001 for female GK versus female WISTAR, and &&&p < 0.01 for female WISTAR versus male WISTAR.