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Schematic diagram for the cardioprotection of luteolin against I/R injury in the diabetic heart. Luteolin initiates nuclear translocation and activation of Nrf2 by activating eNOS and the subsequent S-nitrosylation and inhibition of Keap1, which upregulates the antioxidative gene (HO-1, SOD, GPx, and catalase) expression and inhibits oxidative stress, leading to the decrease of diabetic myocardial I/R injury.
