Figure 5.
Probability that the beneficial variant will rise to a frequency of 50 per cent or greater during the course of an infection. Data are shown from simulations that exclude the effects of mutational load (blue) or include it, either under a multiplicative model of selection (yellow) or under a model incorporating negative epistasis (red). Simulations were conducted with an initial population bottleneck of 5 and a mutation rate of 1.8 × 10−4 per base per generation. Data are shown here for the WF-CM model.