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. Author manuscript; available in PMC: 2020 Apr 19.
Published in final edited form as: ACS Chem Biol. 2019 Mar 12;14(4):579–586. doi: 10.1021/acschembio.8b01049

Figure 1. Histone post-translation modification.

Figure 1.

The nucleosome, the basic subunit of chromatin, consists of an octamer of histone proteins H2A, H2B, H3, and H4 (blue) wrapped by ~147 base pairs of DNA (gray). Histone post-translational modifications (red) are enriched in the tail domains. A list of identified histone modifications is shown below. Abbreviations are: monomethylation (me1), di-methylation (me2), tri-methylation (me3), acetylation (ac), formylation (fo), propionylation (pr), butyrylation (bu), crotonylation (cr), 2-hydroxylisobutyrylation (hib), malonylation (ma), succinylation (su), glutarylation (glu), ubiquitylation (ub), sumoylation (sumo), ADP ribosylation (ar), symmetric di-methylation (me2s), asymmetric di-methylation (me2a), citrullination (cit), phosphorylation (ph) and O-GlcNacylation (og), and hydroxylation (oh).