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. Author manuscript; available in PMC: 2020 Apr 19.
Published in final edited form as: ACS Chem Biol. 2019 Mar 12;14(4):579–586. doi: 10.1021/acschembio.8b01049

Figure 2. Methods for installation of histone PTMs.

Figure 2.

Shown are schematics for (top) genetic installation of modified amino acids, (middle) native chemical ligation and expressed protein ligation, (bottom) cysteine conjugation. Histone components are shown in blue, R* represents the modified side-chain.