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. 2019 Apr 15;10:791. doi: 10.3389/fimmu.2019.00791

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Copyright © 2019 Neidhart, Pajak, Laskari, Riksen, Joosten, Netea, Lutgens, Stroes, Ciurea, Distler, Grigorian and Karouzakis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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S100A4 and PRDM8 associations with the pathogenesis of RA. (A) Significant Spearman's rank correlation between plasma levels of S100A4 and CSF2 (GM-CSF). (B) Significant positive Spearman's rank correlation coefficient between PRDM8 transcription in RA monocytes and plasma levels of CCL5. (C) Significant positive Spearman's rank correlation coefficient between PRDM8 transcription in RA monocytes and plasma levels of IL-6 in patients not receiving Tocilizumab. The units on the X- and Y-axis corresponded to the respective ranks. (D) Decreased PRDM8 transcription in monocytes of patients responding to treatments or in remission (DAS28 < 2.6, BSE < 20 mm/h and CRP < 5 mg/L).