Table 4.
Antileishmanial and antitrypanosomal assays of the EtOAc extracts of the isolated microorganisms showing high antitrypanosomal activity by metabolites of Streptomyces indiaensis RN-205 and Bacillus sp. RN-011.
| Sample Code | L. donovani Promastigote | L. donovani Amastigote | L. donovani Amastigote/THP | T. brucei | THP1 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| IC50 (μg/ml) | IC90 (μg/ml) | IC50 (μg/ml) | IC90 (μg/ml) | IC50 (μg/ml) | IC90 (μg/ml) | IC50 (μg/ml) | IC90 (μg/ml) | IC50 (μg/ml) | IC90 (μg/ml) | |
| RN-205 | >20 | >20 | >20 | >20 | >20 | >20 | <0.8 | 1.03 | >20 | >20 |
| RN-206 | >10 | >10 | >10 | >10 | >10 | >10 | 3.49 | 6.39 | >10 | >10 |
| RN-203 | >20 | >20 | >20 | >20 | >20 | >20 | 4 | 7.62 | >20 | >20 |
| RN-011 | >20 | >20 | >20 | >20 | >20 | >20 | 0.96 | 1.23 | >20 | >20 |
| RN-003 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 |
| RN-107 | >20 | >20 | >20 | >20 | >20 | >20 | 1.11 | 1.66 | >20 | >20 |
| RN-104 | >10 | >10 | >10 | >10 | >10 | >10 | 3.52 | 6.76 | >10 | >10 |
| Amb | 0.165 | 0.212 | 0.308 | 0.361 | 0.147 | 0.213 | ND | ND | ND | ND |
| Pm | 1.661 | 2.594 | 9.946 | ND | 1.050 | 5.915 | ND | ND | ND | ND |
| DFMO | ND | ND | ND | ND | ND | ND | 3.960 | 9.159 | ND | ND |
Amb, Amphotericin B; Pm, Pentamidine; DFMO, Difluoromethylornithine; ND, no data.