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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: DNA Repair (Amst). 2019 Feb 27;77:10–17. doi: 10.1016/j.dnarep.2019.02.010

Figure 1. WA specifically inhibits the SSA sub-pathway of DNA DSB repair.

Figure 1.

(A) I-Scel based GFP reporter assay was employed to evaluate the impact of WA on DSB repair. 0.3 μM WA significantly reduces SSA efficiency but not the other three pathways. p<0.01. (B) Representative FACS illustrations for WA’s effects on MMEJ, NHEJ, FIR, and SSA. Percentage of cells with successfully SSA repair (GFP positive) drops with WA administration. (C) U2OS maintains normal proliferation under the same repair conditions.