Skip to main content
. Author manuscript; available in PMC: 2019 Apr 22.
Published in final edited form as: Alzheimers Dement. 2018 Nov 9;15(3):487–496. doi: 10.1016/j.jalz.2018.09.010

Figure 1. Standard curves of plate-based tau ELISAs and ultra-sensitive tau Simoa assays.

Figure 1

(A) Schematic representation of human tau441 and epitopes of the relevant antibodies. (B) Mid-region (BT2-Tau5), (C) NT1 (Tau12-BT2), (D) NT2 (Tau12-ADx202) and (E) full-length (Tau12-TauAB) ELISAs readily detect human tau with LLoQs ~30 pg/ml. Simoa-based (F) mid-region (BT2-Tau5) (LLoQ ~3.70 pg/ml), and Simoa-based (G) NT1 (BT2-Tau12), (H) NT2 (ADx202-Tau12), and full-length (TauAB-Tau12) assays are shown (LLoQ ~0.27 pg/ml). Each data point is the average ±SEM of three technical replicates. Where the error bars are not visible, the SEM is smaller than the size of the symbol.