Table 2 -.
Discovery cohort (HABS + UCL) | Validation cohort (UCSD) | ||||||
---|---|---|---|---|---|---|---|
NC (HABS, n=10) | NC (UCL, n=9) | AD-MCI (n=21) | AD (n=25) | NC (n=41) | AD-MCI (n=22) | AD (n=23) | |
N (%) or mean ± SD | N (%) or mean ± SD | N (%) or mean ± SD | N (%) or mean ± SD | N (%) or mean ± SD | N (%) or mean ± SD | N (%) or mean ± SD | |
Gender (female) | 7 (70.0) | 7 (77.8) | 16 (76.2) | 13 (52.0) | 27 (56.3) | 10 (45.5) | 12 (52.2) |
Age (years) | 69.8 ± 9.8 | 59.8 ± 6.5 | 65.3 ± 6.7 | 61.0 ± 6.3 | 71.8 ± 6.0 | 73.2 ± 8.1 | 72.4 ± 8.3 |
MMSE | n. a. | 29.4 ± 0.5 | 26.1 ± 1.2 | 20.0 ± 2.9 | 29.3 ± 0.8 | 26.9 ± 1.4 | 19.8 ± 2.4 |
CSF Aβ (pg/ml) | 972.7 ± 199.7 | 950.4 ± 212.0 | 405.2 ± 83.7 | 384.0 ± 130.3 | 947.0 ± 193.3 | 497.3 ± 72.0 | 433.4 ± 84.7 |
CSF Tau (pg/ml) | 236.1 ± 72.2 | 282.1 ± 78.5 | 861.3 ± 373.3 | 921.2 ± 480.4 | 245.6 ± 104.4 | 687.3 ± 214.7 | 641.8 ± 222.3 |
CSF Tau/Aβ ratio | 0.2 ± 0.1 | 0.3 ± 0.1 | 2.4 ± 1.4 | 2.5 ± 1.0 | 0.3 ± 0.1 | 1.4 ± 0.4 | 1.5 ± 0.4 |