Table 3.
Group mean %MPEmax and %FARmax values and (±SEM) for fentanyl, naltrexone, or each fentanyl/naltrexone mixture administered in the warm water tail withdrawal or drug discrimination procedure in male and female rats (n=12–14).
| Drug or Drug Mixture | %MPEmax (± SEM) | %FARmax (± SEM) |
|---|---|---|
| Fentanyl Alone | 100 ± 0 | 98.88 ± 0.79 |
| Fentanyl/Naltrexone (1:0.018) | 95.27 ± 4.73 | NT |
| Fentanyl/Naltrexone (1:0.054) | 54.18 ± 8.72 | 100 ± 0 |
| Fentanyl/Naltrexone (1:0.18) | 9.42 ± 2.44 | 68.71 ± 10.65 |
| Fentanyl/Naltrexone (1:0.30) | NT | 30.32 ± 8.95 |
| Fentanyl/Naltrexone (1:0.54) | NT | 25.16 ± 10.46 |
| (−)-Naltrexone | −0.56 ± 1.88 | 2.75 ± 1.54 |
NT: not tested