Table 3 -. Analyses of allele-specific methylation allele preference agreement between twins.
Results are shown for ASM allele preferences for informative MPRs (heterozygous genotype, above intensity cutoff) in Twin-I and Twin-II of a twin pair; the number of ASM events associated either allele A (A-ASM) or allele B (B-ASM) for each twin are shown (the remaining informative MPRs show biallelic methylation in at least one twin). Observed numbers of matching (Agree) or opposite allele preference (Oppose) between twins are shown as compared to the null hypothesis of random preference by Fisher’s Exact tests.
| Informative Events | Twin-I | Twin-II | Expected | Observed | Pvalue (fisher’s exact) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Twin pair | A-ASM | B-ASM | A-ASM | B-ASM | Agree | Oppose | Agree | Oppose | ||
| T04 | 53004 | 301 | 308 | 617 | 486 | 6 | 6 | 132 | 5 | 2.58E-05 |
| T12 | 53386 | 536 | 593 | 585 | 569 | 12 | 12 | 644 | 0 | 1.81E-19 |
| T14 | 53367 | 273 | 283 | 341 | 386 | 4 | 4 | 268 | 4 | 1.87E-05 |
| T16 | 52897 | 1091 | 1046 | 842 | 687 | 31 | 31 | 952 | 22 | 4.74E-28 |
| T20 | 51969 | 1278 | 1345 | 482 | 427 | 23 | 23 | 270 | 32 | 2.77E-09 |
| T26 | 51923 | 430 | 502 | 925 | 1032 | 18 | 17 | 438 | 0 | 7.27E-22 |
| T27 | 53600 | 341 | 336 | 444 | 407 | 5 | 5 | 274 | 4 | 1.88E-06 |
| T29 | 53116 | 1548 | 1415 | 422 | 423 | 24 | 24 | 351 | 30 | 5.80E-12 |
| T30 | 52707 | 661 | 657 | 804 | 769 | 20 | 20 | 695 | 27 | 4.73E-16 |
| T38 | 51995 | 644 | 664 | 574 | 546 | 14 | 14 | 782 | 0 | 7.48E-23 |
| T39 | 52639 | 705 | 785 | 384 | 359 | 10 | 11 | 190 | 2 | 3.18E-11 |