Table 1:
Abbreviations. Bold terms indicate NCBI human gene symbols (common aliases in parentheses) for key proteins or signaling molecules that are included in the blood-brain barrier development biowiring diagram shown in Figure 4. Plain text abbreviations that do not occur in Figure 4 reflect usage by the original author of the cited text, with standard human gene symbols (NCBI) provided in parentheses.
| Column 1 |
Column 2 |
Column 3 |
|||
|---|---|---|---|---|---|
| Abbreviation | Name | Abbreviation | Name | Abbreviation | Name |
| ABC | ATP-binding cassette transporters | FGF2 (BFGF) | fibroblast growth factor 2 | PECAM1 | platelet and endothelial cell adhesion molecule 1 |
| ABCBl (MDRl, P-gly) | ATP binding cassette subfamily B member 1 (P-glycoprotein) | FLT1 (VEGFR1) | fms related tyrosine kinase 1 (VEGF receptor 1) | PLVAP1 (PV-1) | plasmalemma vesicle associated protein |
| ADGRA2 (GPR124) | adhesion G protein-coupled receptor A2 | FLT4 (VEGFR3) | fms related tyrosine kinase 4 (VEGF receptor 3) | PNVP | perineural vascular plexus |
| AGE | advanced glycation endproducts | FOXC2 | forkhead box C2 | PTCH1 | patch |
| AHR | aryl hydrocarbon receptor | FZD4 | frizzled4 | R&D | research and development |
| ALCAM | activated leukocyte cell adhesion molecule | GD | GD followed by a number indicates human gestational day | RA | retinoic acid |
| ALDH1A1 (RALDH1) | aldehyde dehydrogenase 1 family member A1 | GDNF | glial cell line-derived neurotropic factor | RAGE | AGE receptor |
| ALDH1L1 | aldehyde dehydrogenase 1 family member L1 | GFAP | glial fibrillary acidic protein | RARB | retinoic acid receptor beta |
| ALK5 | TGFB receptor 1 | GFRA1 | GDNF family receptor alpha 1 | RBI | rostral blood island |
| ANG1 (Angpt1) | angiopoietin 1 | GLAST (SLC1A3) | solute carrier family 1 member 3 | RC2 (Nes) | nestin (mouse) |
| ANG2 (Angpt2) | angiopoietin 2 | GSTP1 | glutathione S-transferase pi 1 | RECK | reversion inducing cysteine rich protein with kazal motifs |
| AO | adverse outcome | HCI | high content imaging | RELN | reelin |
| AOP | adverse outcome pathway | HES1 | hes family bHLH transcription factor 1 | SELE | selectin |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | HMGB1 | high mobility group box 1 | SEMA3A | semaphorin 3A |
| ASD | autism spectrum disorder | HTS | high throughput screening | Shh | sonic hedgehog |
| BBB | blood-brain barrier | HUVEC | human umbilical vein endothelial cell | SLC29A1 (ENT1) | solute carrier family 29 member 1 |
| BCRP (ABCG2) | ATP binding cassette subfamily G member 2 | ICAM1 | intercellular adhesion molecule 1 | SLC2A1 (GLUT1) | solute carrier family 2 member 1 |
| BLBP (FABP7) | fatty acid binding protein 7 | IL10 | interleukin 10 | SLC3A2 | solute carrier family 3 member 2 |
| BMP | bone morphogenetic protein | IL1B | interleukin 1 beta | SLC7A5 (LAT1) | solute carrier family 7 member 5 |
| CCL2 | C-C motif chemokine ligand 2 | IL34 | interleukin 34 | SLIT2 | slit guidance ligand 2 |
| CCL20 | C-C motif chemokine ligand 20 | IL4 | interleukin 4 | α-SMA | smooth muscle alpha actin (antibody) |
| CD11b (ITGAM) | integrin subunit alpha M | IL6 | interleukin 6 | SMAD2/3 | SMAD family member 2/3 |
| CD11c (ITGAX) | integrin subunit alpha X | KDR (VEGFR2) | kinase insert domain receptor (VEGF receptor 2) | SMAD2/3 | SMAD family member 2/3 |
| CD45 (PTPRC) | protein tyrosine phosphatase, receptor type C | KE | key event | SMO | smoothened |
| CDH1 | cadherin 1 | LEF1 | lymphoid enhancer binding factor 1 | T3 | triiodothyronine |
| CDH2 | cadherin | LGALS3 | galectin 3 | T4 | thyroxine |
| CDH5 (VE-cadherin) | cadherin 5 | LRP5 | Lipoprotein receptor-related protein | TCDD | 2,3,7,8-tetrachlorodibenzodioxin |
| CLDN3 | claudin 3 | MIE | molecular initiating event | TEER | transendothelial electrical resistance |
| CLDN5 | claudin 5 | MMP2/9 | matrix metallopeptidase 2/9 | TEK (TIE2) | TEK receptor tyrosine kinase |
| CNS | central nervous system | NDP | norrin | TGFB1 | transforming growth factor beta 1 |
| CNTF | ciliary neurotrophic factor | NEUROG1 | neurogenin 1 | TGFBR2 | TGFB receptor 2 |
| CSF1 | colony stimulating factor 1 | NEUROG2 | neurogenin 2 | THR | thyroid hormone receptor |
| CSF1-R | colony stimulating factor 1 receptor | NG2 (CSPG4) | chondroitin sulfate proteoglycan 4 | TJP1 (ZO-1) | tight junction protein 1 |
| CS | Carnegie stage | NICD | notch intracellular domain | TJP2 (ZO-2) | tight junction protein 2 |
| CX3CR1 | C-X3-C motif chemokine receptor 1 | NO | nitric oxide | TNC | tenascin C |
| CXCL2 | C-X-C motif chemokine ligand 2 | NOS | nitric oxide synthase | TNF (TNFA) | tumor necrosis factor |
| CXCL8 (IL8) | C-X-C motif chemokine ligand 8 (interleukin 8) | NOTCH | notch | Tox21 | Toxicology Testing in the 21st Century |
| CYP1B1 | cytochrome P450 family 1 subfamily B member 1 | NPC | neuroprogenitor cell | ToxCast | Toxicity ForeCaster |
| CYP2U1 | cytochrome P450 family 2 subfamily U member 1 | NRARP | notch-regulated ankyrin repeat protein | TS | Thieler stage |
| DIO2 | iodothyronine deiodinase 2 | NRP1 | neuropilin 1 | ToxRefDB | Toxicity Reference Database |
| DLL4 | delta like canonical Notch ligand 4 | NVU | neurovascular unit | TSPAN12 | tetra-spanin protein 12 |
| DNT | developmental neurotoxicity | OATP (SLCO1A2) | solute carrier organic anion transporter family member 1A2 | UGT | UDP-glucuronosyltransferase |
| DMT1 (SLC11A2) | divalent metal transporter | OATP2 | organic anion transporting polypeptide 2 | VCAM1 | vascular cell adhesion molecule 1 |
| E | E followed by a number indicates mouse embryonic day | OCLN | occludin | VEGFA | vascular endothelial growth factor A |
| EGF | epidermal growth factor | PCAP | pial capillary anastomotic plexus | VEGFC | vascular endothelial growth factor C |
| EC | endothelial cell | PDGFB | platelet derived growth factor subunit B | Vmax | maximum velocity |
| EOMES (TBR2) | eomesodermin | PDGFBB | PDGFB homodimer | VTM | virtual tissue model |
| FGF | fibroblast growth factor | PDGFRB | platelet derived growth factor subunit B receptor | Wnt | Wnt signaling pathway |