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Molecular targets of the various Bruton tyrosine kinase (BTK) inhibitors
| Variable | Inhibitor | |||
|---|---|---|---|---|
|
| ||||
| Ibrutinib | Acalabrutinib | Zanubrutinib | Tirabrutinib | |
| Target | BTK | BTK | BTK | BTK |
|
| ||||
| Major off-targets | ITK | Minimal | ITK (weak) | TEC (weak) |
| EGFR | ||||
| TEC | ||||
| BMX | ||||
|
| ||||
| Anti-platelet activity | Yes | No | No | No |
ITK = interleukin 2–inducible T cell kinase; EGFR = epidermal growth factor receptor; TEC = Tec protein tyrosine kinase; BMX = cytoplasmic tyrosine–protein kinase BMX.
