TABLE I.

Principles governing the pan-Canadian Oncology Drug Review’s evaluative framework⁴

Criterion	Definition
Overall clinical benefit
	A measure of the net health benefit of using the drug to diagnose or manage a cancer-related condition (for example, lung cancer) or cancer care–related issue (for example, skeletal-related events in metastatic disease)
Alignment with patient values
	An assessment made after considering information about patient values
Cost effectiveness
	A measure of the net efficiency of the drug and companion technology compared with other drug and nondrug alternatives (no cut-off threshold)
Feasibility of adoption into the health system
	An assessment of the ease with which the drug can be adopted into the overall health care and cancer care systems