Fig. 1.

MiR-152-5p is significantly downregulated in keloids and its’ aberrant expression inhibits the motility and promotes apoptosis of HKFs. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. (A, B) The relative expression of miR-152-5p in HKTs and HKFs, compared with normal control. (C) The proliferation of cells transfected with miR-152-5p mimics at different time was determined by CCK8 assay. (D) The Migration was determined by transwell assay. (E) Flow cytometric analysis revealed the great promotion of apoptosis. (F) The relative expression of Smad3 protein in HKF1 and HKF2 cells was examined by western blot assay.