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. 2019 Apr 22;14(4):e0215547. doi: 10.1371/journal.pone.0215547

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© 2019 Jung et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 8 — (A) Concentration profiles of miR-451 (M) and mTOR (R) fluctuating around the threshold values under regular infusions. Peaks in pseudo-mass are generated when M and R crosses th_M and th_R, respectively. (B) Trajectory of mTOR–miR-451–AMPK concentration profiles switching between proliferation and migration mode. (C) Dynamics of intracellular proteins, mass, and mass_s of the cell cycle model in response to regular glucose and drug infusions.