Table 1. Parameters in the core control (miR-451–AMPK–mTOR) model.

Par	Description	Value	Ref
μG	glucose consumption rate	0.5	[17, 47]
ℓ1	miR-451 autocatalytic production rate	4.0	[14, 17]
ℓ2	Hill-type coefficient	1.0	[14, 17]
α	inhibition strength of miR-451 by AMPK complex	1.6	[14, 17]
thM	threshold of miR-451 for invasion/growth switch	1.84	computed*
ℓ3	AMPK autocatalytic production rate	4.0	[14, 17]
ℓ4	Hill-type coefficient	1.0	[14, 17]
β	inhibition strength of AMPK complex by miR-451	1.0	[14, 17]
thA	threshold of AMPK for invasion/growth switch	1.25	computed*
S1	signaling source of AMPK	0.2	[14, 17]
ϵ1	scaling factor (slow dynamics) of AMPK complex	0.02	[11, 14, 17, 48, 49]
ℓ5	AMPK autocatalytic production rate	4.0	[14, 17]
ℓ6	Hill-type coefficient	1.0	[14, 17]
γ	inhibition strength of AMPK complex by miR-451	1.0	[14, 17]
thR	threshold of mTOR for invasion/growth switch	2.76	computed*
S2	signaling source of mTOR	1.2	[14, 17]
ϵ2	scaling factor (slow dynamics) of mTOR	0.02	[11, 14, 17, 48, 49]
μD	drug decay rate	1.316	[41, 50]

*The values are obtained using Matlab numerical bifurcation toolbox Matcont [46].