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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Pain. 2019 May;160(5):1050–1058. doi: 10.1097/j.pain.0000000000001481

Figure 3. Prophylactic MC depletion does not prevent the development of mechanical pain hypersensitivity following mCHI.

Figure 3.

(A) Scheme of the experimental design. Four days after the end of the MC depletion protocol, or control saline treatment, rats were subjected to baseline behavioral nociceptive testing, followed by mCHI and further behavioral post-mCHI testing, 3–14 days later. Time course changes in cephalic mechanical pain withdrawal thresholds (B) and corresponding cumulative nociceptive score (C) at baseline, 3, 7, and 14 days post mCHI. *** q < 0.0001 (FDR corrected values following Fisher’s LSD post-hoc test at selected time points vs baseline in control animals). ### q < 0.0001 (FDR corrected values following Fisher’s LSD post-hoc test at selected time points vs baseline in 48/80-treated animals).