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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Psychopharmacology (Berl). 2018 Oct 22;236(3):953–962. doi: 10.1007/s00213-018-5075-5

Figure 3.

Figure 3.

Effects of butylone and pentylone on transporter-mediated release in rat brain synaptosomes and cells transfected with human transporters. Data from rat brain synaptosomes are depicted in Panel A for [3H]MPP+ efflux via DAT and Panel B for [3H]5-HT efflux via SERT; effects of butylone and pentylone are shown as closed circles and open squares, respectively. Data from HEK-293 cells are depicted in Panel C for [3H]MPP+ efflux via human DAT and Panel D for [3H]5-HT efflux via human SERT; effects of 10 μM butylone in the presence of Krebs-Henseleit-Phosphate buffer (KHP) or 10 μM monensin are shown as open or closed circles, whereas effects of 10 μM pentylone in the presence of KHP or 10 μM monensin are shown as open or closed squares. Arrows indicate beginning of butylone or pentylone perfusion. Data are mean ± SD for n=3 experiments performed in triplicate.