Figure-1:

Proposed mechanism for Na dependent and Mfsd2a mediated LPC transport across the plasma membrane. Na binds to Mfsd2a and LPC inserts itself into the outer leaflet of the membrane. Then, LPC diffuses laterally into the hydrophobic cleft of Mfsd2a, causing a conformational change in Mfsd2a from the outward-open form to the inward-open form. Thus, LPC is inverted from the outer leaflet to the inner leaflet through a pathway within the transporter (Quek et al., 2016).

LPC: Lysophosphatidylcholine, Na: Sodium.