Figure 3.

Convergent associations between relative abundances of Prevotella and high-altitude environments in different species of mammals. Significant positive correlations were observed between altitude and the relative abundance of Prevotella in wild house mice from Ecuador transect (A) and Bolivia-Brazil transect (B). A similar correlation between altitude and relative abundance of Prevotella was found in Pika (n=102) (Figure generated from data in Li et al. 2016) (C). The relative abundance of Prevotella was higher in Yaks compared to cattle collected from the same farm (elev. 3000m) (D) and in Tibetan sheep (elev. 3000m) compared to sheep (elev. 2200m) (E) (Figure generated from data in Zhang et al. 2016). The relative abundance of Prevotella was higher in Tibetans (3600–4500m) living in high altitudes compared to Han (500–3600m) living in low altitudes (Figure generated from data in Li et al. 2016) (F). In controlled lab settings, intermittent hypoxic exposure in laboratory mice resulted in higher relative abundance of Prevotella compared to controls (Figure generated from data in Moreno-Indias et al. 2015) (G).