Table I.
Effects of prothrombin complex concentrate (PCC) on thromboelastometry, PT and aPTT at 2, 4 and 8 hours (h) after apixaban intake.
| Enrolment day | 3.POD | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Pre-value | 2 h-apix |
2 h-apix-PCC 25 IU/kg |
p-value (2 h-apix-PCC vs 2 h-apix) |
2 h-apix-PCC 50 IU/kg |
p-value (2 h-apix-PCC vs 2 h-apix) |
|
| Apixaban (ng/mL) | 0 (0/0) | 77 (41/95) | 73 (45/100) | 70 (39/95) | ||
|
| ||||||
| CT-Extem (s) | 63 (58/70) | 72 (66/95) | 79 (70/89) | 0.705 | 79 (73/100) | 0.232 |
|
| ||||||
| aPTT (s) | 35.1 (33.6/35.4) | 40.5 (38.1/45.1) | 40.6 (36.2/42.6) | 0.037* | 40.1 (35.9/41.8) | 0.049* |
|
| ||||||
| PT (s) | 13.3 (12.9/13.6) | 14.6 (14.2/15) | 13.3 (12.9/13.7) | 0.002** | 12.9 (12.5/13.4) | 0.002** |
|
| ||||||
| Enrollment day | 3.POD | |||||
|
| ||||||
| Pre-value | 4 h-apix |
4 h-apix-PCC 25 IU/kg |
p-value (4 h-apix-PCC vs 4 h-apix) |
4 h-apix-PCC 50 IU/kg |
p-value (4 h-apix-PCC vs 4 h-apix) |
|
|
| ||||||
| Apixaban (ng/mL) | 0 (0/0) | 92 (62/104) | 88 (57/103) | 87 (56/105) | ||
|
| ||||||
| CT-Extem (s) | 63 (58/70) | 80 (69/97) | 75 (62/93) | 0.232 | 78 (70/91.5) | 0.828 |
|
| ||||||
| aPTT (s) | 35.1 (33.6/35.4) | 42.8 (38/45) | 39.9 (36.4/41.6) | 0.002** | 39.7 (35.3/41.4) | 0.002** |
|
| ||||||
| PT (s) | 13.3 (12.9/13.6) | 14.7 (13.9/15.3) | 13.5 (13.1/14.1) | 0.002** | 12.9 (12.6/13.6) | 0.002** |
|
| ||||||
| Enrollment day | 3.POD | |||||
|
| ||||||
| Pre-value | 8 h-apix |
8 h-apixPCC 25 IU/kg |
p-value (8 h-apix-PCC vs 8 h-apix) |
8 h-apix-PCC 50 IU/kg |
p-value (8 h-apix-PCC vs 8 h-apix) |
|
|
| ||||||
| Apixaban (ng/mL) | 0 (0/0) | 59 (38/95) | 57 (41/94) | 59 (41/91) | ||
| CT-Extem (s) | 63 (58/70) | 75 (66/84) | 72 (65/86) | 0.719 | 73 (66/92) | 0.633 |
| aPTT (s) | 35.1 (33.6/35.4) | 38.6 (35.8/41.8) | 37.4 (34.6/40.1) | 0.084 | 36.2 (34.5/39.6) | 0.059 |
| PT (s) | 13.3 (12.9/13.6) | 14.4 (13.6/15.1) | 13.0 (12.5/13.6) | 0.002** | 12.7 (11.8/13.1) | 0.002** |
POD: post operative day; apix: apixaban; PCC: prothrombin complex concentrate (25 IU/kg=0.35 IU/mL; 50 IU/kg=0.7IU/mL); CT: clotting time; PT: prothrombin time; aPTT: activated partial prothrombin. Times are reported in seconds (s). Data for other parameters are median and 95% confidence interval in brackets. Pairwise Wilcoxon exact test (two-tailed):
*
p<0.05;
**
p<0.01.