Fig. 2.

a Effect of the presence of the APOE*E2 allele, and the genotypes in rs7852872-ASTN2 and rs16914781-SNTG1 on ADAOO. A two-sample t test indicates the presence of the APOE*E2 allele increases the ADAOO by ~ 8.1 years (t₇₂ = 4.67, 95% CI 4.6–11.6, P = 1.37 × 10⁻⁶). Pink, blue, and dotted horizontal lines are, respectively, the within genotype average ADAOO, the individuals’ ADAOO, and the global average ADAOO in our sample. b Effect of the APOE*E2×ASTN2 and APOE*E2×SNTG1 interactions on ADAOO. Green lines symbolize protection, red lines susceptibility, and the gray line the average ADAOO in our sample. Note that the APOE*E2 allele delays ADAOO regardless of the interacting marker. Abbreviations as in Fig. 1