Table 1.

Results of the association analysis for ADAOO in 78 patients with PSEN1 E280A Alzheimer’s disease (a). Proportion of variance explained and gender- and education-specific effects of ADAOO associated SNPs (b)

(a)
Chr	SNPa	Position	Gene	Marker information				Multi-locus linear mixed-effects model
				Ref/Alt	MA (Freq)	CR	Change	β (SEβ)	P	P FDR
19	rs7412	45,412,078	APOE	C/T	T (0.046)	0.974	p.Arg176Cys	8.213 (1.505)	6.48 × 10−7	4.21 × 10−5
9	rs7852872	119,249,338	ASTN2	C/G	G (0.396)	0.987	Intronic	3.684 (0.881)	8.10 × 10−5	2.63 × 10−3
8	rs16914781	51,287,481	SNTG1	A/G	G (0.339)	1.000	Intronic	3.273 (0.872)	3.52 × 10−4	7.62 × 10−3
(b)
SNPa	PVE	Sex			Education group
		χ 2	df	P	χ 2	df	P
rs7412	0.239	0.023	2	0.989	4.303	6	0.636
rs7852872	0.133	1.041	1	0.308	2.681	3	0.443
rs16914781	0.076	0.939	2	0.625	6.331	6	0.387

^aUCSC GRCh37/hg19 coordinates

ADAOO Alzheimer’s disease age of onset, Chr chromosome, SNP single nucleotide polymorphism, Ref/Alt reference/alternate allele, MA minor allele, Freq frequency, CR call rate, β regression coefficient, SE_β standard error of β, P P value, FDR false discovery rate, PVE proportion of variance explained, χ² test statistic, df degrees of freedom