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. 2019 Apr 23;9:6389. doi: 10.1038/s41598-019-42691-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of multigenerational prenatal stress on anxiety-like behaviours in the elevated plus maze (EPM) at P180. Anxiety-like behaviour was indicated by the latency to enter or escape into a closed arm. (A) A representative photograph of a rat escaping into a closed arm of the EPM. (B) Multigenerational stress decreased latency to enter closed arm in F4-SSSS males in comparison to non-stressed males. Asterisks indicate significances: *P < 0.05. All data are presented as mean ± SEM. “b” indicates stress effect.