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. 2019 Apr 23;9:6374. doi: 10.1038/s41598-019-42932-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rapamycin and DON additively ameliorated the arthritis in SKG mice. (A) SKG mice with ZyA-induced arthritis were given thrice-weekly intraperitoneal injections of vehicle (n = 11), 3 mg/kg rapamycin (Rapa, n = 12), 1.6 mg/kg DON (n = 11), or 3 mg/kg rapamycin plus 1.6 mg/kg DON (Rapa + DON; n = 13). We recorded clinical arthritis scores for the mice up to day 62 after the ZyA injection, and compared the final scores between mice treated by the various drugs regimens; bracket shows differences between mice treated with Rapa + DON and those treated by (a) Rapa or (b) DON alone. (B) The hind paws of SKG mice were evaluated for histopathological changes on day 62 after the ZyA injection. Specimens were stained with hematoxylin and eosin; original magnification 40×. (C) Histologic scores in the left hind paw for SKG mice treated with vehicle (n = 5), Rapa (n = 5), DON (n = 6), or Rapa + DON (n = 6). Bars show mean ± SEM. ^*P < 0.05.