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. 2019 Apr 16;10:681. doi: 10.3389/fmicb.2019.00681

Table 2.

Patients suffering from proven invasive fungal disease.

Center Frankfurt Frankfurt Vienna Vienna Vienna Vienna Vienna Vienna Vienna Vienna
Sex/age (years) m/11.3 m/4.7 m/1.8 m/11.5 f/16.5 f/14.9 m/16.3 m/14.6 f/9.5 m/16.0
Malignancy (risk group) Rhabdo CGD ALL (SR) ALL (SR) ALL (HR) AML AML ALL (relapse) AML (relapse) AML (relapse)
Chemo/ HSCT HSCT HSCT Chemo Chemo Chemo HSCT HSCT Chemo Chemo Chemo
Time point Post-engraft Pre-engraft Induction Re-induction Induction Pre-engraft pre-engraft Induction Induction Induction
Risk factors S N N, S S N, S N N N N N
Pathogen C. krusei A. fumigatus C. albicans A. fum./Rhizopus arrhizus mold Fusarium spp. C. krusei mold C. albicans C. krusei
Site Blood (culture) Lung, brain biopsy (culture) Blood (culture) Sinus/maxilla surgery (culture) Lung biopsy (histology) Eye/blood/skin (culture skin and blood) Blood (culture) Lung biopsy (histology) Blood (culture) Blood (culture)
Prophylaxis Antimold (LAMB) Antimold (Vori) No No Antimold (LAMB/Vori) Antimold (Posa) No Antimold (Vori) Antimold (Vori) Antimold (Posa)
Outcome IFD CR Death CR PR CR CR Death CR CR CR
Outcome Death unrelated to IFD Death due to IFD Alive Alive Alive Alive Death due to IFD Death unrelated to IFD Death unrelated to IFD Death unrelated to IFD

F, female; m, male; AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; ALL-SR, ALL-standard-risk group; ALL-HR, ALL-high-risk group; rhabdo rhabdomyosarcoma; CGD, chronic granulomatous disease; chemo chemotherapy; HSCT, hematopoietic stem cell transplantation; engraft engraftment; N, prolonged neutropenia (<500 neutrophils/mm3 >10 days); S use of corticosteroids at a mean minimum dose of 0.3 mg/kg/day prednisone equivalent for more than 3 weeks; LAMB, liposomal amphotericin B; Vori voriconazole; Posa posaconazole; CR, complete remission; PR, partial remission; IFD, invasive fungal disease.