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. 2019 Apr 16;7:247. doi: 10.3389/fchem.2019.00247

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Copyright © 2019 Piras, Sanna, Carta, Corona, Ibba, Loddo, Madeddu, Caria, Aulic, Laurini, Fermeglia and Pricl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(Top) Inhibition of RSV (m.o.i = 1) by addition of 10d (20 μM) at different times (filled circles). Data for untreated virus (open circles) and for addition of 6-azauridine (filled squares) are also shown for comparison. Data represent mean values from two independent determinations; variation among duplicate samples was <15%. (Bottom) Immunofluorescence attachment assay: (a,b) RSV A2 non-treated control; (c,d) 6-azauridine does inhibit viral attachment; (e,f) dextran sulfate inhibits viral attachment; (g,h) 10d does not inhibit viral attachment. Bound virus is detected by indirect immunofluorescence with an anti-G monoclonal antibody, followed by an Alexa Fluor 488-labeled secondary antibody (a,e,c,g, green). Nuclei are visualized using 4′,6-diamidino-2-phenylindole (b,f,d,h, blue).