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. 2019 Apr 16;10:338. doi: 10.3389/fgene.2019.00338

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Copyright © 2019 Masaki, Ikeda, Hata, Shiozawa, Kon, Ogawa, Suzuki, Hakuno, Takahashi and Kataoka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SRSF2 mutants promote exon 9.5 of EZH2 gene through binding to CCWG motif. (A) Sequence logos for the motifs enriched in inclusion-type exons with WT, P95H, P95L, and P95R are presented. (B) Sequence logos for the motifs enriched in inclusion-type exons with WT, P95H, P95L, and P95R are shown. (C) Sequence of exon 9.5 (pseudo exon) in human EZH2 gene. In frame stop codons are underlined. CCWG motif, found with SRSF2 P95H and P95R proteins in (B), are indicated with open boxes. (D) Splicing pattern of EZH2 pre-mRNA in myc-vector, SRSF2 WT, P95H, P95L, and P95R are indicated. The ratio of exon9.5 included product in total splicing products is shown beneath the panel. The schematic representations of PCR products are shown at the right side of the panel. RT, Reverse Transcriptase. M, DNA size marker.