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A model for splicing changes caused by SRSF2 mutations in the patients. (Left) SRSF2 wild-type protein binds to purine-rich exonic splicing enhancer for promotion of exon recognition. (Right) SRSF2 mutants, SRSF2 P95H and P95R, preferentially bind to CCWG motif-containing exons to promote aberrant splicing.
