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. 2019 Apr 16;10:400. doi: 10.3389/fphar.2019.00400

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Copyright © 2019 Sachs, Döhl, Weber, Bonus, Ehlers, Fleischer, Klinger, Gohlke, Pietruszka, Schmitt and Teusch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of 3,4-dihydroisocoumarins on ABC transporter activity. Cancer cell lines overexpressing (A) P-gp (HCT-15), (B) BCRP (MCF-7/MX), or (C) MRP1 (H69AR) were incubated with test compounds and intracellular fluorescence of the substrates calcein-AM (P-gp, MRP1) or Hoechst 33342 (BCRP) was measured over 3 h. Data were normalized to DMSO (0% inhibition) and the positive controls PSC833, Ko143, and MK-571, respectively (100% inhibition). Bars represent mean ± SEM of at least three independent experiments. nd, not determined because of intrinsic fluorescence.