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. 2019 Apr 16;10:400. doi: 10.3389/fphar.2019.00400

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Copyright © 2019 Sachs, Döhl, Weber, Bonus, Ehlers, Fleischer, Klinger, Gohlke, Pietruszka, Schmitt and Teusch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Liquid drug assays of the 12 3,4-dihydroisocoumarins and S. cerevisiae strains expressing Pdr5 WT or the mutant Pdr5 EQ. (A) The influence of 14, (R)-19, (S)-19, 3, 4, 21, and 16 on growth of strains expressing Pdr5 WT. (B) The influence of 14, (R)-19, (S)-19, 3, 4, 21, and 16 on growth of strains expressing Pdr5 EQ. (C) The influence of (R)-19a, (S)-19a, 16a and ellagic acid on growth of strains expressing Pdr5 WT. (D) The influence of (R)-19a, (S)-19a, 16a and ellagic acid on growth of strains expressing Pdr5 EQ. Cells were incubated at different concentrations of the compounds for 48 h at 30 °C and OD₆₀₀ was determined.